Scher has been a partner in the New York office of Pentagram since 1991. She began her career as an art director in the 1970s and early 80s, when her eclectic approach to typography became highly influential. In the mid 1990s her landmark identity for The Public Theater fused high and low into a wholly new symbology for cultural institutions, and her recent architectural collaborations have re-imagined the urban landscape as a dynamic environment of dimensional graphic design. Her graphic identities for Citibank and Tiffany & Co. have become case studies for the contemporary regeneration of American brands.

Scher has developed identity and branding systems, promotional materials, environmental graphics, packaging and publication designs for a broad range of clients that includes, among others, Bloomberg, Microsoft, Coca-Cola, Bausch + Lomb, Perry Ellis, the Museum of Modern Art, Jazz at Lincoln Center, the Metropolitan Opera, the New York City Ballet, the New York Philharmonic, the Detroit Symphony Orchestra, the New Jersey Performing Arts Center, the New 42nd Street, the New York Botanical Garden, the United States Holocaust Memorial Museum, the Robin Hood Foundation and The Daily Show With Jon Stewart. In 1996 Scher’s widely imitated identity for The Public Theater won the coveted Beacon Award for integrated corporate design strategy.

During the course of her career Scher has been the recipient of hundreds of industry honors and awards. In 1998 she was named to the Art Directors Club Hall of Fame, and in 2000 she received the Chrysler Award for Innovation in Design. She has served on the national board of the American Institute of Graphic Arts (AIGA) and was president of its New York Chapter from 1998 to 2000. In 2001 she was awarded the profession’s highest honor, the AIGA Medal, in recognition of her distinguished achievements and contributions to the field, and in 2006 she was awarded the Type Directors Club Medal. In 2012 she was honored with the Philadelphia Museum of Art’s Design Collab Award, and in 2013 she received the National Design Award for Communication Design, presented by the Cooper-Hewitt, National Design Museum. Scher has been a member of the Alliance Graphique Internationale (AGI) since 1993 and was elected its president in 2009.

Scher holds a BFA from the Tyler School of Art and honorary doctorates from the Corcoran College of Art and Design, the Maryland Institute College of Art, and Moore College of Art and Design. She has lectured and exhibited all over the world She has served on the board of directors of The Public Theater, and in 2006 she was named to the Design Commission of the City of New York.

Her work has been exhibited all over the world and is represented in the permanent collections of the Museum of Modern Art and the Cooper-Hewitt National Design Museum in New York, the Library of Congress in Washington, D.C., the Philadelphia Museum of Art, the Denver Art Museum, the Victoria and Albert Museum, London, the Museum für Gestaltung Zürich, and the Bibliothèque nationale de France and the Centre Georges Pompidou in Paris. Her teaching career includes over two decades at the School of Visual Arts, along with positions at the Cooper Union, Yale University and the Tyler School of Art. She is the author of Make It Bigger (2002) and MAPS (2011), both published by Princeton Architectural Press.